(The Mount Sinai Hospital / Mount Sinai School of Medicine Summary)
It has been shown in previous research that dietary restriction, to a degree, is effective in helping to prevent aging and disease, but the mechanism has not been clear. Researchers at Mount Sinai School of Medicine have now found a major clue that could help 'solve' the mysteries of aging and disease.
Published in the November 17 edition of the journal Public Library of Science Biology, the study examines how dietary restriction and a high-caloric diet influence biochemical responses. The researchers found that, under certain conditions, a lower-calorie diet slows the development of some age-related conditions such as Alzheimer's disease, in addition to the aging process. The way in which the diet is restricted doesn't appear to matter.
Charles Mobbs, PhD, Professor of Neuroscience and of Geriatrics and Palliative Medicine at Mount Sinai School of Medicine, said "It may not be about counting calories or cutting out specific nutrients, but how a reduction in dietary intake impacts the glucose metabolism, which contributes to oxidative stress." Meanwhile, a high calorie diet may accelerate age-related disease by promoting oxidative stress.
Read more about this fascinating study in the article called "Scientists Find Molecular Trigger That Helps Prevent Aging and Disease" from ScienceDaily (Nov. 18, 2009)